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This reaction breaks the disulfide bonds, converting them into two thiol groups, and facilitates targeted drug release where it is needed most
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A static representation of the topology and electrostatic field in the H-site (Warshel, 1998) will have to be complemented with a description of the dynamics of the entire molecule (Hammes et al., 2011), and possibly invoke effects of the adjacent subunit of the dimeric enzyme for a deeper insight into structural requirements for the isomerization mechanism
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